How To Prevent Tick Bites That Cause Lyme Disease The Blacklegged Tick is every outdoorsman's worst nightmare next to bigfoot. These ticks transmit bacteria to humans and other animals that cause Lyme disease. Two notable doctors working for the Centers for Disease Control insist that they know of the best methods for preventing Lyme disease. Given their extensive research on Lyme disease, I am inclined to follow their advice, which focuses on personal protection and controlling the bacteria that causes Lyme disease in the environment.